Past and future episodic detail retrieval is reduced among clinically normal older adults at higher genetic risk for late-onset Alzheimer's disease.

Document Type

Article

Abstract

OBJECTIVE: Remembering and imagining personal events that are rich in episodic (i.e., event-specific) detail is compromised in older adults who have mild cognitive impairment, a known risk factor for Alzheimer's disease dementia. Less clear is whether lower episodic detail generation is associated with higher risk for Alzheimer's disease dementia before mild clinical decline is detectable.

METHOD: We compared past and future autobiographical thinking in clinically normal older adult carriers of the Alzheimer's disease-associated apolipoprotein E e4 allele (APOE4;

RESULTS: APOE4 carriers showed a significant reduction for episodic details when remembering past events (

CONCLUSIONS: These findings suggest that APOE4 is associated with a selective reduction of episodic detail during past and future autobiographical thinking among clinically normal older adults. Reduced episodic detail generation, therefore, may be an early cognitive associate of higher risk for Alzheimer's disease dementia. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Medical Subject Headings

Humans; Aged; Alzheimer Disease; Cognitive Dysfunction; Forecasting; Apolipoprotein E4; Risk Factors; Memory, Episodic

Publication Date

2-1-2023

Publication Title

Neuropsychology

ISSN

1931-1559

Volume

37

Issue

2

First Page

194

Last Page

203

PubMed ID

36442007

Digital Object Identifier (DOI)

10.1037/neu0000866

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