Progressive Neuropsychologic Impairment and Hypoxemia: Relationship in Chronic Obstructive Pulmonary Disease
Document Type
Article
Abstract
In previous work we showed that patients with chronic obstructive pulmonary disease (COPD) suffered decrements in neuropsychologic functioning suggestive of organic mental disturbance. This study combined data from two multicenter clinical trials to explore the nature and possible determinants of such neuropsychologic change. Three groups of patients with COPD whose hypoxemia was mild (N = 86), moderate (N =155), or severe (N = 61) were compared with age- and education-matched nonpatients (N = 99). The rate of neuropsychologic deficit rose from 27% in mild hypoxemia to 61% in severe hypoxemia. Various neuropsychologic abilities declined at different rates, suggesting differential vulnerability of neuropsychologic functions to progress of COPD. Multivariate analyses revealed a consistent significant relationship between degree of hypoxemia and neuropsychologic impairment, but the amount of shared variance was small (7%). Increasing age and lower education were also associated with impairment. © 1987, American Medical Association. All rights reserved.
Publication Date
1-1-1987
Publication Title
Archives of General Psychiatry
ISSN
0003990X
E-ISSN
15383636
Volume
44
Issue
11
First Page
999
Last Page
1006
PubMed ID
3675139
Digital Object Identifier (DOI)
10.1001/archpsyc.1987.01800230079013
Recommended Citation
Grant, Igor; Prigatano, George P.; Heaton, Robert K.; McSweeny, A. John; Wright, Elizabeth C.; and Adams, Kenneth M., "Progressive Neuropsychologic Impairment and Hypoxemia: Relationship in Chronic Obstructive Pulmonary Disease" (1987). Clinical Neuropsychology. 237.
https://scholar.barrowneuro.org/neuropsychology/237