Enhanced negative feedback responses in remitted depression.
Document Type
Article
Abstract
Major depressive disorder (MDD) is characterized by hypersensitivity to negative feedback that might involve frontocingulate dysfunction. MDD patients exhibit enhanced electrophysiological responses to negative internal (errors) and external (feedback) cues. Whether this dysfunction extends to remitted depressed (RD) individuals with a history of MDD is currently unknown. To address this issue, we examined the feedback-related negativity in RD and control participants using a probabilistic punishment learning task. Despite equivalent behavioral performance, RD participants showed larger feedback-related negativities to negative feedback relative to controls; group differences remained after accounting for residual anxiety and depressive symptoms. The present findings suggest that abnormal responses to negative feedback extend to samples at increased risk for depressive episodes in the absence of current symptoms.
Medical Subject Headings
Adult; Analysis of Variance; Brain Mapping; Conflict, Psychological; Contingent Negative Variation; Depression; Electroencephalography; Feedback; Female; Gyrus Cinguli; Humans; Male; Neuropsychological Tests; Photic Stimulation; Probability Learning; Reaction Time; Time Factors
Publication Date
7-2-2008
Publication Title
Neuroreport
ISSN
0959-4965
Volume
19
Issue
10
First Page
1045
Last Page
1048
PubMed ID
18580576
Digital Object Identifier (DOI)
10.1097/WNR.0b013e3283036e73
Recommended Citation
Santesso, Diane L; Steele, Katherine T; Bogdan, Ryan; Holmes, Avram J; Deveney, Christen M; Meites, Tiffany M; and Pizzagalli, Diego A, "Enhanced negative feedback responses in remitted depression." (2008). Clinical Neuropsychology. 11.
https://scholar.barrowneuro.org/neuropsychology/11