Title

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

Document Type

Article

Abstract

A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease. © 2007 Nature Publishing Group.

Publication Date

11-1-2007

Publication Title

Nature Medicine

ISSN

10788956

E-ISSN

1546170X

Volume

13

Issue

11

First Page

1359

Last Page

1362

PubMed ID

17934472

Digital Object Identifier (DOI)

10.1038/nm1653

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