Title

Can platelet BACE1 levels be used as a biomarker for Alzheimer's disease? Proof-of-concept study

Document Type

Article

Abstract

To date there is no validated peripheral biomarker to assist with the clinical diagnosis of Alzheimer's disease (AD). Platelet proteins have been studied as AD biomarkers with relative success. In this study, we investigated whether platelet BACE1 levels differ between AD and cognitively normal (CN) control patients. Using a newly developed ELISA method, we found that BACE1 levels were significantly lower in AD compared to CN subjects. These data were supported by the observation that several BACE1 isoforms, identified by Western blotting, were also lower in AD platelets. This proof-of-concept study provides evidence for testing platelet BACE1 levels as a peripheral AD biomarker using a novel, sensitive and inexpensive method. © 2013 Informa UK Ltd.

Publication Date

4-8-2013

Publication Title

Platelets

ISSN

09537104

E-ISSN

13691635

Volume

24

Issue

3

First Page

235

Last Page

238

PubMed ID

22775589

Digital Object Identifier (DOI)

10.3109/09537104.2012.688899

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