Untreated type 2 diabetes and its complications are associated with subcortical infarctions
OBJECTIVE - To investigate the association of type 2 diabetes with subcortical infarctions. RESEARCH DESIGN AND METHODS - We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging. RESULTS - The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11- 6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects. CONCLUSIONS - These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions. © 2011 by the American Diabetes Association.
Digital Object Identifier (DOI)
Roberts, Rosebud O.; Kantarci, Kejal; Geda, Yonas E.; Knopman, David S.; Przybelski, Scott A.; Weigand, Stephen D.; Petersen, Ronald C.; and Jack, Clifford R., "Untreated type 2 diabetes and its complications are associated with subcortical infarctions" (2011). Neurology. 422.