Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future


Yonas E. Geda, Mayo Clinic Scottsdale-Phoenix, ArizonaFollow
Lon S. Schneider, University of Southern California
Laura N. Gitlin, Johns Hopkins University
David S. Miller, Bracket
Gwenn S. Smith, Johns Hopkins School of Medicine
Joanne Bell, Pfizer Global Research and Development
Jovier Evans, National Institute of Mental Health (NIMH)
Michael Lee, University of Minnesota Twin Cities
Anton Porsteinsson, University of Rochester School of Medicine and Dentistry
Krista L. Lanctôt, Sunnybrook Health Sciences Centre
Paul B. Rosenberg, Johns Hopkins School of Medicine
David L. Sultzer, David Geffen School of Medicine at UCLA
Paul T. Francis, King's College London
Henry Brodaty, UNSW Medicine
Prasad P. Padala, Geriatric Research Education and Clinical Center
Chiadikaobi U. Onyike, Johns Hopkins School of Medicine
Luis Agüera Ortiz, Centro de Investigación Biomédica En Red de Salud Mental
Sonia Ancoli-Israel, Department of Psychiatry
Donald L. Bliwise, Wesley Woods Health Center
Jennifer L. Martin, David Geffen School of Medicine at UCLA
Michael V. Vitiello, University of Washington, Seattle
Kristine Yaffe, University of California, San Francisco
Phyllis C. Zee, Northwestern University Feinberg School of Medicine
Nathan Herrmann, Sunnybrook Health Sciences Centre
Robert A. Sweet, University of Pittsburgh
Clive Ballard, King's College London
Ni A. Khin, Center for Drug Evaluation and Research
Cara Alfaro, Center for Drug Evaluation and Research
Patrick S. Murray, University of Pittsburgh
Susan Schultz, University of Iowa Carver College of Medicine
Constantine G. Lyketsos, Johns Hopkins School of Medicine

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Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis. © 2013 The Alzheimer¢s Association. All rights reserved.

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Alzheimer's and Dementia







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