Apoe ε4 genotype and the risk for subjective cognitive impairment in elderly persons

Document Type

Article

Abstract

© 2015, American Psychiatric Association. All rights reserved. The authors compared the risk for subjective cognitive impairment (SCI) between carriers of the apolipoprotein E ε4 (APOE ε4) allele (cases) and APOE ε4 noncarriers (controls). SCI was assessed by a validated self-reported questionnaire. The authors used multivariable logistic regression analyses to compute odds ratios and 95% confidence intervals adjusted for age, sex, education, and marital status. Data were available on 114 participants (83 women; 47 APOE ε4 carriers; mean age, 69 years). The risk for SCI was significantly higher among cases than controls, particularly for those 70 years of age and older. These findings should be considered preliminary until confirmed by a prospective cohort study.

Publication Date

1-1-2015

Publication Title

Journal of Neuropsychiatry and Clinical Neurosciences

ISSN

08950172

Volume

27

Issue

4

First Page

322

Last Page

325

PubMed ID

25803305

Digital Object Identifier (DOI)

10.1176/appi.neuropsych.14100268

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