Title

Cortical thickness and anxiety symptoms among cognitively normal elderly persons: The mayo clinic study of aging

Document Type

Article

Abstract

© 2017, American Psychiatric Association. All rights reserved. The authors conducted a cross-sectional study to investigate the association between anxiety symptoms and cortical thickness, as well as amygdalar volume. A total of 1,505 cognitively normal participants, aged $70 years, were recruited from the Mayo Clinic Study of Aging in Olmsted County, Minnesota, on whom Beck Anxiety Inventory and 3T brain MRI data were available. Even though the effect sizes were small in this community-dwelling group of participants, anxiety symptoms were associated with reduced global cortical thickness and reduced thickness within the frontal and temporal cortex. However, after additionally adjusting for comorbid depressive symptoms, only the association between anxiety symptoms and reduced insular thickness remained significant.

Publication Date

1-1-2017

Publication Title

Journal of Neuropsychiatry and Clinical Neurosciences

ISSN

08950172

Volume

29

Issue

1

First Page

60

Last Page

66

PubMed ID

27578447

Digital Object Identifier (DOI)

10.1176/appi.neuropsych.15100378

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