Deep brain stimulation and cognitive outcomes among patients with Parkinson’s disease: A historical cohort study
© 2019, American Psychiatric Association. All rights reserved. Objective: Deep brain stimulation (DBS) is an effective treatment for motor symptoms of Parkinson’s disease; however, there is conflicting literature about the effect of DBS on cognitive function. The authors conducted a historical cohort study involving patients with Parkinson’s disease who underwent DBS of the globus pallidus pars interna (GPi; N=12) or subthalamic nucleus (STN; N=17). Methods: The authors i nvesti gated di fferences i n four neuropsychol ogi cal test scores at 6 months post-DBS (follow-up) as compared with baseline (i.e., Boston Naming Test, WAIS Verbal Comprehension Index [WAIS-VCI], Working Memory Index [WAIS-WMI], and Processing Speed Index [WAIS-PSI]). Results: GPi DBS patients showed no difference between baseline and follow-up on any neuropsychological test. STN DBS patients had lower scores indicating decreased performance at follow-up as compared with baseline on WAIS-PSI (mean [SD], 91.47 [10.42] versus 81.65 [12.03]; p=0.03). There was a significant (p=0.008) difference between the change in baseline to follow-up scores on the WAIS-VCI for the STN DBS and GPi DBS groups (i.e., STN DBS patients scored lower at the 6-month follow-up compared with baseline, whereas GPi DBS patients scored higher). Conclusions: GPi may be a preferred target for DBS in patients with Parkinson’s disease when considering cognitive outcomes.
Journal of Neuropsychiatry and Clinical Neurosciences
Digital Object Identifier (DOI)
Hansen, Allison L.; Krell-Roesch, Janina; Kirlin, Kristin A.; Limback-Stokin, Martin M.; Roesler, Kimberly; Velgos, Stefanie N.; Lyons, Mark K.; Geda, Yonas E.; and Mehta, Shyamal H., "Deep brain stimulation and cognitive outcomes among patients with Parkinson’s disease: A historical cohort study" (2019). Neurology. 342.