Title

Replication of Association Between ELAVL4 and Parkinson Disease: The GenePD Study

Department

neurology

Document Type

Article

Abstract

Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in ELAVL4 in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the Gene PD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal P value = 0.011) in the Gene PD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene. © Springer-Verlag 2008.

Medical Subject Headings

neurology

Publication Date

2008

Publication Title

Human Genetics

ISSN

3406717

Volume

124

Issue

1

First Page

95

Last Page

99

Digital Object Identifier (DOI)

10.1007/s00439-008-0526-4

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