Title

Huntington CAG Repeat Size Does Not Modify Onset Age in Familial Parkinson's Disease: The GenePD Study

Department

neurology

Document Type

Article

Abstract

The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 LRRK2 carriers. All cases had HD CAG repeats (range, 15-34) below the clinical range for HD, although 5.2% of the sample (n = 25) had repeats in the intermediate range (the intermediate range lower limit = 27; upper limit = 35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD. © 2008 Movement Disorder Society.

Medical Subject Headings

neurology

Publication Date

2008

Publication Title

Movement Disorders

ISSN

8853185

Volume

23

Issue

11

First Page

1596

Last Page

1601

Digital Object Identifier (DOI)

10.1002/mds.22186

This document is currently not available here.

Share

COinS