Association Between Pathology and Electroencephalographic Activity in Parkinson's Disease
Introduction. The key mechanisms that connect Parkinsonâ€™s disease pathology with dementia are unclear. We tested the hypothesis that the quantitative spectral electroencephalographic measure, delta bandpower, correlates with Lewy type synucleinopathy on pathological examination in Parkinsonâ€™s disease. As a corollary hypothesis, we analyzed whether there would be delta bandpower electroencephalographic differences between Parkinsonâ€™s disease dementia cases with and without pathological criteria for Alzheimerâ€™s disease. Methods. We used pathological examination results from 44 Parkinsonâ€™s disease subjects from our brain bank with various degrees of cognitive decline, who had undergone electroencephalography. Pathological grading for Lewy type synucleinopathy, plaques, tangles, and indications of vascular pathology in subcortical and cortical areas were correlated with the most associated electroencephalographic biomarker with Parkinsonâ€™s disease dementia in our laboratory, delta bandpower. Group differences for all spectral electroencephalographic measures were also analyzed between cases with and without pathological criteria for Alzheimerâ€™s disease. Results. Findings revealed significant correlations between delta bandpower with Lewy type synucleinopathy, whereas indications of Alzheimerâ€™s disease or vascular pathology had nonsignificant correlation. The strongest association was with delta bandpower and Lewy type synucleinopathy in the anterior cingulate region. Mean delta bandpower was higher in the group for Parkinsonâ€™s disease dementia with Alzheimerâ€™s disease pathology criteria than without. Conclusions. Lewy type synucleinopathy severity appears to be more associated with increased delta bandpower than with Alzheimerâ€™s disease pathology or indications of vascular pathology over all cases. However, the presence of Alzheimerâ€™s pathology may associate with more cortex physiological disruption in a subset of cases.
Medical Subject Headings
Clinical EEG and Neuroscience
Digital Object Identifier (DOI)
Caviness, John N.; Beach, Thomas G.; Hentz, Joseph G.; Shill, Holly A.; Driver-Dunckley, Erika D.; and Adler, Charles H., "Association Between Pathology and Electroencephalographic Activity in Parkinson's Disease" (2018). Neurology. 215.