A Theoretical Analysis of the Synergy of Amyloid and Tau in Alzheimer's Disease
Amyloid plaques and Tau protein neurofibrillary tangles are considered the two most important pathogenic factors in Alzheimer's disease. The prevailing amyloid cascade hypothesis suggests that amyloid-Î² (AÎ²) elevation induces downstream Tau hyperphosphorylation and aggregation, synaptic dysfunction, and neuronal loss that ultimately results in cognitive impairment. Alternatively, the dual-pathway hypothesis suggests that AÎ² and abnormal Tau are two independent factors that exert synergistic effects on synaptic dysfunction and neuronal loss. We hypothesize that the intrinsic interaction of AÎ² and Tau would better predict cognitive impairment. Herein, we propose an AÎ²-Tau interactive model based on a review of the medical literature, mathematic modeling, and analysis of our clinicopathological data.
Medical Subject Headings
Journal of Alzheimer's Disease
Digital Object Identifier (DOI)
Han, Pengcheng and Shi, Jiong, "A Theoretical Analysis of the Synergy of Amyloid and Tau in Alzheimer's Disease" (2016). Neurology. 173.