Title

A Quantitative Analysis of Brain Soluble Tau and the Tau Secretion Factor

Department

neurology

Document Type

Article

Abstract

Neurofibrillary tangles (NFTs) represent products of insoluble tau protein in the brains of patients with Alzheimer disease (AD). The cerebrospinal fluid (CSF) tau level is a biomarker in AD diagnosis. The soluble portion of tau protein in brain parenchyma is presumably the source for CSF tau but this has not previously been quantified. We measured CSF tau and soluble brain tau at autopsy in temporal and frontal brain tissue samples from 7 cognitive normal, 12 mild cognitively impaired, and 19 AD subjects. Based on the measured brain soluble tau, we calculated the whole brain tau load and estimated tau secretion factor. Our results suggest that the increase in NFT in AD is likely attributable to post-translational processes; the increase in CSF tau in AD patients is due to an accelerated carrier-based secretion. Moreover, cognitive dysfunction assessed by final Mini-Mental State Examination scores correlated with the secretion factor but not with the soluble tau.

Medical Subject Headings

neurology

Publication Date

2017

Publication Title

Journal of Neuropathology and Experimental Neurology

ISSN

223069

Volume

76

Issue

1

First Page

44

Last Page

51

Digital Object Identifier (DOI)

10.1093/jnen/nlw105

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