Impaired Self-Awareness of Motor Deficits in Parkinson's Disease: Association With Motor Asymmetry and Motor Phenotypes
Background: This study investigated impaired self-awareness of motor deficits in nondemented, nondepressed Parkinson's disease (PD) patients during a defined clinical on state. Methods: Twenty-eight PD patients were examined. Patients' self-ratings and experts' ratings of patients' motor performance were compared. Patient-examiner discrepancies and level of impairment determined severity of impaired self-awareness. Motor exam assessed overall motor functioning, hemibody impairment, and 4 motor phenotypes. Neuropsychological tests were also conducted. Results: Signs of impaired self-awareness were present in 17 patients (60.7%). Higher severity of impaired self-awareness correlated significantly with higher postural-instability and gait-difficulty off scores (r = .575; P = .001), overall motor off scores (r = .569; P = .002), and higher left hemibody off scores (r = .490; P = .008). In multiple linear regression analyses, higher postural-instability and gait-difficulty off scores remained as the only significant predictor of impaired self-awareness severity. Conclusions: Postural instability and gait difficulties, disease severity, and right hemisphere dysfunction seem to contribute to impaired self-awareness.
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Maier, Franziska; Prigatano, George P.; Kalbe, Elke; Barbe, Michael T.; Eggers, Carsten; Lewis, Catharine J.; Burns, Richard S.; Morrone-Strupinsky, Jeannine; Moguel-Cobos, Guillermo; Fink, Gereon R.; and Timmermann, Lars, "Impaired Self-Awareness of Motor Deficits in Parkinson's Disease: Association With Motor Asymmetry and Motor Phenotypes" (2012). Neurology. 130.