Title

Mild cognitive impairment and dementia in motor manifest Huntington's disease: Classification and prevalence

Document Type

Article

Abstract

OBJECTIVES: To identify the characteristics and prevalence of mild cognitive impairment in patients with motor-manifest Huntington's disease (HD) and to propose a new mild cognitive impairment (HD-MCI) classification for HD. METHODS: We included 307 motor-manifest HD participants from the ENROLL-HD study who completed the evaluation in four neurocognitive domains including executive functions, processing speed, language, and memory. Cognitive impairment in each domain was determined by age- and education-adjusted cutoffs (> 1.5 standard deviations below the mean). HD-MCI was defined as an impairment in at least one cognitive domain without a loss of functional independence (Function Independence Scale, FIS ≥85). Dementia (HD-Dem) was defined as at least two domains of cognitive impairment with functional impairment (FIS ≤80). RESULTS: At the onset of motor symptoms, MCI was present in 84% and dementia in 5% of patients. After 5 years of motor symptoms, 24% of participants met the criteria for MCI and 69% for dementia. Executive dysfunction was the most common impairment, being present in 70% of participants, followed by slowed processing speed in 67%. Language impairment was reported in 55% and memory deficits in 53%. MCI subtypes were classified as "Executive-predominant" (executive impairment and slowed processing speed), "Representational-predominant" (impaired language and memory) and "Mixed Executive-Representational". Executive-predominant MCI comprised 30%, Representational-predominant 15% and Mixed 55% of this cohort. CONCLUSION: MCI is highly prevalent in the early stage of motor-manifest HD. Three MCI subgroups are defined suggesting at the earlier stage of this disease the frontal-striatal-executive and/or the temporoparietal-representational functional network can be impaired.

Medical Subject Headings

Adolescent; Adult; Aged; Aged, 80 and over; Cognitive Dysfunction (classification, diagnosis, epidemiology); Cohort Studies; Dementia (classification, diagnosis, epidemiology); Executive Function (physiology); Female; Humans; Huntington Disease (classification, diagnosis, epidemiology); Male; Mental Status and Dementia Tests; Middle Aged; Neuropsychological Tests; Prevalence; Young Adult

Publication Date

1-15-2020

Publication Title

Journal of the neurological sciences

E-ISSN

1878-5883

Volume

408

First Page

116523

PubMed ID

31678902

Digital Object Identifier (DOI)

10.1016/j.jns.2019.116523

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