Title

Is There Room for Non-Dopaminergic Treatment in Parkinson Disease?

Department

neurology

Document Type

Article

Abstract

Although levodopa and dopaminergic drugs remain the mainstay of therapy for the motor symptoms of Parkinson disease (PD), they fail to address many of the non-motor symptoms of PD including orthostatic hypotension, freezing of gait (FOG) and difficulty with balance, drug-induced paranoia and hallucinations, and drug-induced dyskinesias. Droxidopa, a drug that increases norepinephrine, treats orthostatic hypotension, cholinomimetic drugs sometimes help with FOG and difficulty with balance, pimavanserin, a drug that blocks serotonin receptors, treats paranoia and hallucinations, and anti-glutaminergic drugs treat dyskinesias. Thus, there are ample opportunities for non-dopaminergic drugs in PD. © 2012 Springer-Verlag Wien.

Medical Subject Headings

neurology

Publication Date

2013

Publication Title

Journal of Neural Transmission

ISSN

3009564

Volume

120

Issue

2

First Page

347

Last Page

348

Digital Object Identifier (DOI)

10.1007/s00702-012-0946-0

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