Herpesvirus Infections and Risk of Parkinson's Disease
INTRODUCTION: Herpesviruses might play a role in the pathogenesis of neurodegenerative disorders. We sought to examine a possible association between alpha herpesvirus infections and Parkinson's disease. METHODS: We conducted a population-based case-control study of incident Parkinson's disease in 2009 Medicare beneficiaries age 66-90 years (89,790 cases, 118,095 randomly selected comparable controls). We classified beneficiaries with any diagnosis code for "herpes simplex" and/or "herpes zoster" in the previous 5 years as having had the respective alpha herpesviruses. In beneficiaries with Part D prescription coverage, we also identified those prescribed anti-herpetic medications. We calculated odds ratios (OR) and 95% CI between alpha herpesvirus diagnosis/treatment and Parkinson's disease with logistic regression, with adjustment for age, sex, race/ethnicity, smoking, and use of medical care. RESULTS: Parkinson's disease risk was inversely associated with herpes simplex (OR 0.79, 95% CI 0.74-0.84), herpes zoster (OR 0.88, 95% CI 0.85-0.91), and anti-herpetic medications (OR 0.87, 95% CI 0.80-0.96). CONCLUSION: Herpesvirus infection or treatment might reduce risk of Parkinson's disease, but future studies will be required to explore whether this inverse association is causal.
Medical Subject Headings
Aged; Aged, 80 and over; Case-Control Studies; Female; Herpes Zoster; Herpesviridae Infections (epidemiology); Humans; Male; Medicare; Parkinson Disease (epidemiology); Risk Factors; United States (epidemiology)
Digital Object Identifier (DOI)
Camacho-Soto, Alejandra; Faust, Irene; Racette, Brad A.; Clifford, David B.; Checkoway, Harvey; and Searles Nielsen, Susan, "Herpesvirus Infections and Risk of Parkinson's Disease" (2020). Neurology. 1133.