Botulinum toxin B reduces sialorrhea in parkinsonism
We report on our open-label experience with botulinum toxin B for the treatment of severe sialorrhea associated with parkinsonism. Nine adult patients with parkinsonism and medically intractable sialorrhea were treated with botulinum toxin B (1,000 units into each parotid gland using superficial landmarks). After treatment, patients experienced a 61% mean subjective improvement and a 42% mean reduction of quantitative saliva production. There were no adverse effects seen in any subjects. Mean peak benefit from injections lasted 14 weeks. We conclude that denervation of salivary glands with botulinum toxin B produces excellent reduction of excessive salivation associated with parkinsonism.
Medical Subject Headings
Aged; Aged, 80 and over; Botulinum Toxins (therapeutic use); Botulinum Toxins, Type A; Humans; Middle Aged; Parkinsonian Disorders (complications); Salivation (drug effects); Sialorrhea (drug therapy, etiology); Treatment Outcome
Movement disorders : official journal of the Movement Disorder Society
Digital Object Identifier (DOI)
Racette, Brad A.; Good, Laura; Sagitto, Sandy; and Perlmutter, Joel S., "Botulinum toxin B reduces sialorrhea in parkinsonism" (2003). Neurology. 1107.