Title

Tau immunotherapies for Alzheimer's disease

Document Type

Article

Abstract

INTRODUCTION: Alzheimer's dementia (AD) is the most common form of dementia in the World. Pathologically, it is characterized by extracellular β-amyloid plaques and intraneuronal neurofibrillary tangles (NFTs). The latter is composed of irregular, pathological forms of the tau protein. Currently, FDA-approved symptomatic treatments are limited to the targeting of cholinergic deficits and glutamatergic dysfunctions. However, as understanding of β-amyloid plaques and NFTs expands, these dysfunctional proteins represent potential therapeutic interventions. The present review article evaluates active and passive immunotherapies in clinical development for AD to date and their potential to significantly improve the treatment of AD going forward. AREAS COVERED: All clinical trials that have targeted β-amyloid to date have produced somewhat disappointing results, leading to a shift in intervention focus to targeting tau protein. A key component in understanding the value of targeting tau in therapeutic paradigms has come from the conceptualization of prion-like pathological spread of tau isoforms from neuron to neuron, and referred to as 'tauons'. Immunotherapies currently under investigation include approaches aiming at preventing pathological tau aggregation, stabilizing microtubules, and blocking of tauons. EXPERT OPINION: A multi-targeted approach that would use biologics targeting tau offers great promise to the development of effective AD therapeutic interventions.

Medical Subject Headings

Alzheimer Disease (immunology, physiopathology, therapy); Amyloid beta-Peptides (metabolism); Animals; Biological Products (pharmacology); Humans; Immunotherapy (methods); Molecular Targeted Therapy; Neurofibrillary Tangles (metabolism); tau Proteins (immunology, metabolism)

Publication Date

6-1-2019

Publication Title

Expert opinion on investigational drugs

E-ISSN

1744-7658

Volume

28

Issue

6

First Page

545

Last Page

554

PubMed ID

31094578

Digital Object Identifier (DOI)

10.1080/13543784.2019.1619694

This document is currently not available here.

Share

COinS