Title

Quantitative EEG as a predictive biomarker for Parkinson disease dementia

Document Type

Article

Abstract

Objective: We evaluated quantitative EEG (QEEG) measures as predictive biomarkers for the development of dementia in Parkinson disease (PD). Preliminary work shows that QEEG measures correlate with current PD cognitive state. A reliable predictive QEEG biomarker for PD dementia (PD-D) incidence would be valuable for studying PD-D, including treatment trials aimed at preventing cognitive decline in PD. Methods: A cohort of subjects with PD in our brain donation program utilizes annual premortem longitudinal movement and cognitive evaluation. These subjects also undergo biennial EEG recording. EEG from subjects with PD without dementia with follow-up cognitive evaluation was analyzed for QEEG measures of background rhythm frequency and relative power in ω, θ, α, and β bands. The relationship between the time to onset of dementia and QEEG and other possible predictors was assessed by using Cox regression. Results: The hazard of developing dementia was 13 times higher for those with low background rhythm frequency (lower than the grand median of 8.5 Hz) than for those with high background rhythm frequency (p < 0.001). Hazard ratios (HRs) were also significant for > median θ bandpower (HR = 3.0; p = 0.004) compared to below, and for certain neuropsychological measures. The HRs for ω, α, and β bandpower as well as baseline demographic and clinical characteristics were not significant. Conclusion: The QEEG measures of background rhythm frequency and relative power in the θ band are potential predictive biomarkers for dementia incidence in PD. These QEEG biomarkers may be useful in complementing neuropsychological testing for studying PD-D incidence. © 2011 by AAN Enterprises, Inc.

Publication Date

7-12-2011

Publication Title

Neurology

ISSN

00283878

E-ISSN

1526632X

Volume

77

Issue

2

First Page

118

Last Page

124

PubMed ID

21633128

Digital Object Identifier (DOI)

10.1212/WNL.0b013e318224af8d

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