Title

Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans

Document Type

Article

Abstract

Background Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known. Objective To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures. Design A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial. Measurements Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH ≤65 pg/ml), (ii) low 25-OH D and normal PTH and (iii) low 25-OH D and high PTH. Results Age, gender and season-adjusted regression analyses showed that PTH was directly correlated with total (P = 0·02), truncal (P = 0·03) and extremity (P = 0·03) fat mass, while 25-OH D was inversely related to truncal fat mass (P = 0·02). Total fat mass in groups 1-3, respectively, was 30·0, 34·0 and 37·4 kg (P = 0·008); truncal fat mass was 13·4, 15·9 and 17·6 kg (P = 0·006) and extremity fat mass was 15·8, 16·9 and 19·7 kg (P = 0·02). Lean mass did not differ across the three groups. Conclusions Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA. © 2010 Blackwell Publishing Ltd.

Publication Date

5-1-2010

Publication Title

Clinical Endocrinology

ISSN

03000664

E-ISSN

13652265

Volume

72

Issue

5

First Page

595

Last Page

603

PubMed ID

19656160

Digital Object Identifier (DOI)

10.1111/j.1365-2265.2009.03676.x

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