Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2

Authors

Allen Rosenspire, Wayne State University School of Medicine
Wonsuk Yoo, Wayne State University School of MedicineFollow
Sherri Menard, Wayne State University School of Medicine
Anthony R. Torres, Utah State University

Document Type

Article

Abstract

We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism. © 2011 International Society for Autism Research, Wiley Periodicals, Inc.

Keywords

Anti-transglutaminase antibody, Immunology, Pediatrics

Publication Date

8-1-2011

Publication Title

Autism Research

ISSN

19393792

E-ISSN

19393806

Volume

4

Issue

4

First Page

242

Last Page

249

PubMed ID

21506289

Digital Object Identifier (DOI)

10.1002/aur.194

Recommended Citation

Rosenspire, Allen; Yoo, Wonsuk; Menard, Sherri; and Torres, Anthony R., "Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2" (2011). Translational Neuroscience. 907.
https://scholar.barrowneuro.org/neurobiology/907