Title

Cloning of cdna and genomic dna encoding human type xviii collagen and localization of the α1(xviii) collagen gene to mouse chromosome 10 and human chromosome 21

Document Type

Article

Abstract

Types XV and XVIII collagen belong to a unique and novel subclass of the collagen superfamily for which we have proposed the name the MULTIPLEXIN family. Members of this class contain polypeptides with multiple triple-helical domains separated and flanked by non-triple-helical regions. In this paper, we report the isolation of human cDNAs and genomic DNAs encoding the α1(XVIII) collagen chain. Utilizing a genomic clone as probe, we have mapped the COL18A1 gene to chromosome 21q22.3 by fluorescence in situ hybridization. In addition, using an interspecific backcross panel, we have shown that the murine Col18a1 locus is on chromosome 10, close to the loci for Col6a1 and Col6a2. © 1994 Academic Press. All rights reserved.

Publication Date

1-1-1994

Publication Title

Genomics

ISSN

08887543

E-ISSN

10898646

Volume

19

Issue

3

First Page

494

Last Page

499

PubMed ID

8188291

Digital Object Identifier (DOI)

10.1006/geno.1994.1098

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