Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones
We have isolated overlapping cDNAs encoding the N-terminal non-triple- helical region of mouse α1(XVIII) collagen and shown that three different variants of α1(XVIII) collagen exist. Each of the three variants shows characteristic tissue-specific expression patterns. Immunohistochemical studies show positive staining for α1(XVIII) collagen along the basement membrane zones of vessels in the intestinal villi, the choroid plexus, skin, liver, and kidney. Thus, we conclude that α1(XVIII) collagen may interact (directly or indirectly) with components in basement membrane zones or on the basal surface of endothelial/epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America
Digital Object Identifier (DOI)
Muragaki, Yasuteru; Timmons, Sheila; Griffith, C. May; Oh, Suk P.; Fadel, Bahaa; Quertermous, Thomas; and Olsen, Bjorn R., "Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones" (1995). Neurobiology. 721.