Title

Plasmonic-Based Electrochemical Impedance Imaging Of Electrical Activities In Single Cells

Department

neurobiology

Document Type

Article

Abstract

Studying electrical activities in cells, such as action potential and its propagation in neurons, requires a sensitive and non-invasive analytical tool that can image local electrical signals with high spatial and temporal resolutions. Here we report a plasmonic-based electrochemical impedance imaging technique to study transient electrical activities in single cells. The technique is based on the conversion of the electrical signal into a plasmonic signal, which is imaged optically without labels. We demonstrate imaging of the fast initiation and propagation of action potential within single neurons, and validate the imaging technique with the traditional patch clamp technique. We anticipate that the plasmonic imaging technique will contribute to the study of electrical activities in various cellular processes.

Publication Date

1-1-2017

Publication Title

Angewandte Chemie - International Edition

ISSN

14337851

Volume

56

Issue

30

First Page

8855

Last Page

8859

Digital Object Identifier (DOI)

10.1002/anie.201703033

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