Title

Neuronal Nicotinic Acetylcholine Receptors Serve As Sensitive Targets That Mediate β-Amyloid Neurotoxicity

Department

neurobiology

Document Type

Article

Abstract

Alzheimer's disease (AD) is the most common form of brain dementia characterized by the accumulation of β-amyloid peptides (Aβ) and loss of forebrain cholinergic neurons. Aβ accumulation and aggregation are thought to contribute to cholinergic neuronal degeneration, in turn causing learning and memory deficits, but the specific targets that mediate Aβ neurotoxicity remain elusive. Recently, accumulating lines of evidence have demonstrated that Aβ directly modulates the function of neuronal nicotinic acetylcholine receptors (nAChRs), which leads to the new hypothesis that neuronal nAChRs may serve as important targets that mediate Aβ neurotoxicity. In this review, we summarize current studies performed in our laboratory and in others to address the question of how Aβ modulates neuronal nAChRs, especially nAChR subunit function. ©2006 CPS and SIMM.

Publication Date

10-1-2006

Publication Title

Acta Pharmacologica Sinica

ISSN

16714083

Volume

27

Issue

10

First Page

1277

Last Page

1286

Digital Object Identifier (DOI)

10.1111/j.1745-7254.2006.00430.x

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