Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability, and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.
Digital Object Identifier (DOI)
Liu, Qiang; Xin, Wei; He, Ping; Turner, Dharshaun; Yin, Junxiang; Gan, Yan; Shi, Fu Dong; and Wu, Jie, "Interleukin-17 Inhibits Adult Hippocampal Neurogenesis" (2014). Translational Neuroscience. 441.