Heteromeric Î±7Î²2 Nicotinic Acetylcholine Receptors In The Brain
The Î±7 nicotinic acetylcholine receptor (Î±7 nAChR) is highly expressed in the brain, where it maintains various neuronal functions including (but not limited to) learning and memory. In addition, the protein expression levels of Î±7 nAChRs are altered in various brain disorders. The classic rule governing Î±7 nAChR assembly in the mammalian brain was that it was assembled from five Î±7 subunits to form a homomeric receptor pentamer. However, emerging evidence demonstrates the presence of heteromeric Î±7 nAChRs in heterologously expressed systems and naturally in brain neurons, where Î±7 subunits are co-assembled with Î²2 subunits to form a novel type of Î±7Î²2 nAChR. Interestingly, the Î±7Î²2 nAChR exhibits distinctive function and pharmacology from traditional homomeric Î±7 nAChRs. We review recent advances in probing the distribution, function, pharmacology, pathophysiology, and stoichiometry of the heteromeric Î±7Î²2 nAChR, which have provided new insights into the understanding of a novel target of cholinergic signaling.
Trends in Pharmacological Sciences
Digital Object Identifier (DOI)
Wu, Jie; Liu, Qiang; Tang, Pei; Mikkelsen, Jens D.; Shen, Jianxin; Whiteaker, Paul; and Yakel, Jerrel L., "Heteromeric Î±7Î²2 Nicotinic Acetylcholine Receptors In The Brain" (2016). Neurobiology. 429.