Title

Quantitative [18F]Fmiso Pet Imaging Shows Reduction Of Hypoxia Following Trastuzumab In A Murine Model Of Her2+ Breast Cancer

Department

neurobiology

Document Type

Article

Abstract

Purpose: Evaluation of [18F]fluoromisonidazole ([18F]FMISO)-positron emission tomography (PET) imaging as a metric for evaluating early response to trastuzumab therapy with histological validation in a murine model of HER2+ breast cancer. Procedures: Mice with BT474, HER2+ tumors, were imaged with [18F]FMISO-PET during trastuzumab therapy. Pimonidazole staining was used to confirm hypoxia from imaging. Results: [18F]FMISO-PET indicated significant decreases in hypoxia beginning on day 3 (P < 0.01) prior to changes in tumor size. These results were confirmed with pimonidazole staining on day 7 (P < 0.01); additionally, there was a significant positive linear correlation between histology and PET imaging (r2 = 0.85). Conclusions: [18F]FMISO-PET is a clinically relevant modality which provides the opportunity to (1) predict response to HER2+ therapy before changes in tumor size and (2) identify decreases in hypoxia which has the potential to guide subsequent therapy.

Publication Date

2-1-2017

Publication Title

Molecular Imaging and Biology

ISSN

15361632

Volume

19

Issue

1

First Page

130

Last Page

137

Digital Object Identifier (DOI)

10.1007/s11307-016-0994-1

This document is currently not available here.

Share

COinS