Tenascin-C Is Associated With Cored Amyloid-B Plaques In Alzheimer Disease And Pathology Burdened Cognitively Normal Elderly
Tenascin-C (TN-C) is an extracellular matrix glycoprotein linked to inflammatory processes in pathological conditions including Alzheimer disease (AD). We examined the distribution of TN-C immunoreactivity (ir) in relation to amyloid-Î² (AÎ²) plaques and vascular Ab deposits in autopsy brain tissues from 14 patients with clinical and neuropathological AD and 10 aged-matched controls with no cognitive impairment; 5 of the controls had AÎ² plaques and 5 did not. TN-C ir was abundant in cortical white matter and subpial cerebral gray matter in all cases, whereas TN-C ir was weak in blood vessels. In all cases with AÎ² plaques but not in plaque-free controls, TN-C ir was detected as large (>100 mm in diameter) diffuse extracellular deposits in cortical grey matter. TN-C plaques completely overlapped and surrounded cored AÎ² plaques labeled with X-34, a fluorescent derivative of Congo red, and they were associated with reactive astrocytes astrocytes, microglia and phosphorylated taucontaining dystrophic neurites. Diffuse AÎ² plaques lacking amyloid cores, reactive glia or dystrophic neurites showed no TN-C ir. In cases with cerebral amyloid angiopathy, TN-C ir in vessel walls did not spread into the surrounding neuropil. These results suggest a role for TN-C in AÎ² plaque pathogenesis and its potential as a biomarker and therapy target.
Journal of Neuropathology and Experimental Neurology
Digital Object Identifier (DOI)
Mi, Zhiping; Halfter, Willi; Abrahamson, Eric E.; Klunk, William E.; Mathis, Chester A.; Mufson, Elliott J.; and Ikonomovic, Milos D., "Tenascin-C Is Associated With Cored Amyloid-B Plaques In Alzheimer Disease And Pathology Burdened Cognitively Normal Elderly" (2016). Translational Neuroscience. 346.