Neuropathological Correlates Of Amyloid Pet Imaging In Down Syndrome
Down syndrome (DS) results in an overproduction of amyloid-Î² (AÎ²) peptide associated with early onset of Alzheimer's disease (AD). DS cases have AÎ² deposits detectable histologically as young as 12â€“30Â years of age, primarily in the form of diffuse plaques, the type of early amyloid pathology also seen at pre-clinical (i.e., pathological aging) and prodromal stages of sporadic late onset AD. In DS subjects aged >40Â years, levels of cortical AÎ² deposition are similar to those observed in late onset AD and in addition to diffuse plaques involve cored plaques associated with dystrophic neurites (neuritic plaques), which are of neuropathological diagnostic significance in AD. The purpose of this review is to summarize and discuss findings from amyloid PET imaging studies of DS in reference to postmortem amyloid-based neuropathology. PET neuroimaging applied to subjects with DS has the potential to (a) track the natural progression of brain pathology, including the earliest stages of amyloid accumulation, and (b) determine whether amyloid PET biomarkers predict the onset of dementia. In addition, the question that is still incompletely understood and relevant to both applications is the ability of amyloid PET to detect AÎ² deposits in their earliest form.
Digital Object Identifier (DOI)
Abrahamson, Eric E.; Head, Elizabeth; Lott, Ira T.; Handen, Benjamin L.; Mufson, Elliott J.; Christian, Bradley T.; Klunk, William E.; and Ikonomovic, Milos D., "Neuropathological Correlates Of Amyloid Pet Imaging In Down Syndrome" (2019). Translational Neuroscience. 338.