Microglia Changes Associated To Alzheimer'S Disease Pathology In Aged Chimpanzees
In Alzheimer's disease (AD), the brain's primary immune cells, microglia, become activated and are found in close apposition to amyloid beta (AÎ²) protein plaques and neurofibrillary tangles (NFT). The present study evaluated microglia density and morphology in a large group of aged chimpanzees (n = 20, ages 37â€“62 years) with varying degrees of AD-like pathology. Using immunohistochemical and stereological techniques, we quantified the density of activated microglia and morphological variants (ramified, intermediate, and amoeboid) in postmortem chimpanzee brain samples from prefrontal cortex, middle temporal gyrus, and hippocampus, areas that show a high degree of AD pathology in humans. Microglia measurements were compared to pathological markers of AD in these cases. Activated microglia were consistently present across brain areas. In the hippocampus, CA3 displayed a higher density than CA1. AÎ²42 plaque volume was positively correlated with higher microglial activation and with an intermediate morphology in the hippocampus. AÎ²42-positive vessel volume was associated with increased hippocampal microglial activation. Activated microglia density and morphology were not associated with age, sex, pretangle density, NFT density, or tau neuritic cluster density. Aged chimpanzees displayed comparable patterns of activated microglia phenotypes as well as an association of increased microglial activation and morphological changes with AÎ² deposition similar to AD patients. In contrast to human AD brains, activated microglia density was not significantly correlated with tau lesions. This evidence suggests that the chimpanzee brain may be relatively preserved during normal aging processes but not entirely protected from neurodegeneration as previously assumed.
Journal of Comparative Neurology
Digital Object Identifier (DOI)
Edler, Melissa K.; Sherwood, Chet C.; Meindl, Richard S.; Munger, Emily L.; Hopkins, William D.; Ely, John J.; Erwin, Joseph M.; Perl, Daniel P.; Mufson, Elliott J.; Hof, Patrick R.; and Raghanti, Mary Ann, "Microglia Changes Associated To Alzheimer'S Disease Pathology In Aged Chimpanzees" (2018). Neurobiology. 331.