Nicotine And Inflammatory Neurological Disorders

Authors

Wen Hua Piao
Denise Campagnolo
Carlos Dayao
Ronald J. Lukas, Barrow Neurological InstituteFollow
Jie Wu, Barrow Neurological InstituteFollow
Fu Dong Shi, Barrow Neurological InstituteFollow

Department

neurobiology

Document Type

Article

Abstract

Cigarette smoke is a major health risk factor which significantly increases the incidence of diseases including lung cancer and respiratory infections. However, there is increasing evidence that smokers have a lower incidence of some inflammatory and neurodegenerative diseases. Nicotine is the main immunosuppressive constituent of cigarette smoke, which inhibits both the innate and adaptive immune responses. Unlike cigarette smoke, nicotine is not yet considered to be a carcinogen and may, in fact, have therapeutic potential as a neuroprotective and anti-inflammatory agent. This review provides a synopsis summarizing the effects of nicotine on the immune system and its (nicotine) influences on various neurological diseases. © 2009 CPS and SIMM.

Publication Date

6-1-2009

Publication Title

Acta Pharmacologica Sinica

ISSN

16714083

Volume

30

Issue

6

First Page

715

Last Page

722

Digital Object Identifier (DOI)

10.1038/aps.2009.67

Recommended Citation

Piao, Wen Hua; Campagnolo, Denise; Dayao, Carlos; Lukas, Ronald J.; Wu, Jie; and Shi, Fu Dong, "Nicotine And Inflammatory Neurological Disorders" (2009). Translational Neuroscience. 253.
https://scholar.barrowneuro.org/neurobiology/253