Immunohistochemical Localization Of Nicotinic Î²2 And Î±4 Receptor Subunits In Normal Human Brain And Individuals With Lewy Body And Alzheimer'S Disease: Preliminary Observations
Optimum immunohistochemical methods were established to immuno-localize nicotinic acetylcholine receptor Î±4 and Î²2 subunits in temporal cortex and substantia nigra of normal aged and diseased human brain; in normal aged brain, fibers were immunoreactive for both the Î±4 and Î²2 subunits of the nicotinic receptor in the temporal codex and the substantia nigra. In the codex of normal aged brain, rare neurofibrillary tangles occurring could be identified with either anti-Î±4 or anti-Î²2 antibodies, but existing senile plaques were demonstrable with neither. In Alzheimer's disease temporal cortex, there were diminished numbers of nicotinic receptor subunit immunoreactive fibers, and there were appreciable numbers of neuropil threads, neurofibrillary tangles and senile plaques immunoreactive with both the Î±4 and Î²2 antibodies.
Digital Object Identifier (DOI)
Sparks, D. Larry; Beach, Thomas G.; and Lukas, Ronald J., "Immunohistochemical Localization Of Nicotinic Î²2 And Î±4 Receptor Subunits In Normal Human Brain And Individuals With Lewy Body And Alzheimer'S Disease: Preliminary Observations" (1998). Translational Neuroscience. 232.