Longitudinal Assessment of Intravoxel Incoherent Motion Diffusion-Weighted MRI Metrics in Cognitive Decline.
BACKGROUND: Advanced diffusion-based MRI biomarkers may provide insight into microstructural and perfusion changes associated with neurodegeneration and cognitive decline.
PURPOSE: To assess longitudinal microstructural and perfusion changes using apparent diffusion coefficient (ADC) and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) parameters in cognitively impaired (CI) and healthy control (HC) groups.
STUDY TYPE: Prospective/longitudinal.
POPULATION: Twelve CI patients (75% female) and 13 HC subjects (69% female).
FIELD STRENGTH/SEQUENCE: 3 T; Spin-Echo-IVIM-DWI.
ASSESSMENT: Two MRI scans were performed with a 12-month interval. ADC and IVIM-DWI metrics (diffusion coefficient [D] and perfusion fraction [f]) were generated from monoexponential and biexponential fits, respectively. Additionally, voxel-based correlations were evaluated between change in Montreal Cognitive Assessment (ΔMoCA) and baseline imaging parameters.
STATISTICAL TESTS: Analysis of covariance with sex and age as covariates was performed for main effects of group and time (false discovery rate [FDR] corrected) with post hoc comparisons using Bonferroni correction. Partial-η
RESULTS: Significant differences were found for the main effects of group (HC vs. CI) and time. For group effects, higher ADC, IVIM-D, and IVIM-f were observed in the CI group compared to HC (ADC: 1.23 ± 0.08
DATA CONCLUSION: These findings demonstrate that longitudinal differences between CI and HC cohorts can be measured using IVIM-based metrics.
LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY STAGE: 2.
Journal of magnetic resonance imaging : JMRI
Digital Object Identifier (DOI)
Bergamino, Maurizio; Burke, Anna; Baxter, Leslie C; Caselli, Richard J; Sabbagh, Marwan N; Talboom, Joshua S; Huentelman, Matthew J; and Stokes, Ashley M, "Longitudinal Assessment of Intravoxel Incoherent Motion Diffusion-Weighted MRI Metrics in Cognitive Decline." (2022). Translational Neuroscience. 2189.