Striatal Extracts from Patients with Parkinson’s Disease Promote Dopamine Neuron Growth in Mesencephalic Cultures

Authors

P. M. Carvey, Rush University Medical Center
L. R. Ptak, Rush University Medical Center
S. T. Nath, Rush University Medical Center
D. K. Sierens, Rush University Medical Center
E. J. Mufson, Rush University Medical Center
C. G. Goetz, Rush University Medical Center
H. L. Klawans, Rush University Medical Center

Document Type

Article

Abstract

The caudate, putamen, and cerebellum from five patients with Parkinson's disease (PD) and five normal, aged controls were studied to determine if cell-free extracts from these tissues influenced dopamine neuron growth in culture. Cultures incubated with extracts of the caudate and putamen, but not the cerebellum, from PD patients contained more tyrosine hydroxylase immunoreactive neurons than aged controls. These data suggest that the parkinsonian striatum compensates for dopamine loss by increasing neurotrophic factor production. © 1993 Academic Press, Inc.

Publication Date

1-1-1993

Publication Title

Experimental Neurology

ISSN

00144886

E-ISSN

10902430

Volume

120

Issue

1

First Page

149

Last Page

152

PubMed ID

8097475

Digital Object Identifier (DOI)

10.1006/exnr.1993.1049

Recommended Citation

Carvey, P. M.; Ptak, L. R.; Nath, S. T.; Sierens, D. K.; Mufson, E. J.; Goetz, C. G.; and Klawans, H. L., "Striatal Extracts from Patients with Parkinson’s Disease Promote Dopamine Neuron Growth in Mesencephalic Cultures" (1993). Translational Neuroscience. 1956.
https://scholar.barrowneuro.org/neurobiology/1956