Degeneration in the spinal cord of old rats
Silver impregnation of spinal cords of young, adult, and old male Fischer 344 rats revealed an age-related loss of axons in the spinal gray and white matter. Beginning at 455 days of age, the animals showed degenerating fibers in the dorsal horn, intermediate gray, and ventral horn regions as well as in the fasciculus gracilis at the cervical, thoracic, and lumbar levels of the spinal cord. Axonal degeneration was not seen in the fasciculus cuneatus at any of the spinal cord levels examined. Degeneration was greatest in the gray matter of thoracic and in the dorsal columns of the cervical spinal cord levels. There were no differences in the quality of degeneration between the 15-, 17-, 24-, and 28-month-old animals. © 1980, All rights reserved.
Digital Object Identifier (DOI)
Mufson, Elliott J. and Stein, Donald G., "Degeneration in the spinal cord of old rats" (1980). Translational Neuroscience. 1774.