Title

Degeneration in the spinal cord of old rats

Document Type

Article

Abstract

Silver impregnation of spinal cords of young, adult, and old male Fischer 344 rats revealed an age-related loss of axons in the spinal gray and white matter. Beginning at 455 days of age, the animals showed degenerating fibers in the dorsal horn, intermediate gray, and ventral horn regions as well as in the fasciculus gracilis at the cervical, thoracic, and lumbar levels of the spinal cord. Axonal degeneration was not seen in the fasciculus cuneatus at any of the spinal cord levels examined. Degeneration was greatest in the gray matter of thoracic and in the dorsal columns of the cervical spinal cord levels. There were no differences in the quality of degeneration between the 15-, 17-, 24-, and 28-month-old animals. © 1980, All rights reserved.

Publication Date

1-1-1980

Publication Title

Experimental Neurology

ISSN

00144886

Volume

70

Issue

1

First Page

179

Last Page

186

PubMed ID

7418767

Digital Object Identifier (DOI)

10.1016/0014-4886(80)90016-3

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