Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons
Document Type
Article
Abstract
Ibotenic acid injections into the nucleus basalis (Ch4) resulted in a near-total loss of cortical cholinesterase fibers. This loss of cholinergic input is irreversible for at least 6 months. The degeneration of cholinergic input has no transsynaptic effect upon the number of cortical somatostatinergic, cholinergic and cholinesterase-positive (cholinoceptive) neurons. © 1987.
Keywords
Cholinergic, Cortex, Immunohistochemistry, Nucleus basalis, Rat, Somatostatin
Publication Date
8-11-1987
Publication Title
Brain Research
ISSN
00068993
Volume
417
Issue
2
First Page
385
Last Page
388
PubMed ID
2888515
Digital Object Identifier (DOI)
10.1016/0006-8993(87)90470-7
Recommended Citation
Mufson, E. J.; Kehr, A. D.; Wainer, B. H.; and Mesulam, M. M., "Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons" (1987). Translational Neuroscience. 1765.
https://scholar.barrowneuro.org/neurobiology/1765