Title

Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons

Document Type

Article

Abstract

Ibotenic acid injections into the nucleus basalis (Ch4) resulted in a near-total loss of cortical cholinesterase fibers. This loss of cholinergic input is irreversible for at least 6 months. The degeneration of cholinergic input has no transsynaptic effect upon the number of cortical somatostatinergic, cholinergic and cholinesterase-positive (cholinoceptive) neurons. © 1987.

Keywords

Cholinergic, Cortex, Immunohistochemistry, Nucleus basalis, Rat, Somatostatin

Publication Date

8-11-1987

Publication Title

Brain Research

ISSN

00068993

Volume

417

Issue

2

First Page

385

Last Page

388

PubMed ID

2888515

Digital Object Identifier (DOI)

10.1016/0006-8993(87)90470-7

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