Title

Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

Document Type

Article

Abstract

As part of a safety and tolerability study, a 65-year-old man with Parkinson's disease (PD) received monthly intracerebroventricular injections of glial-derived neurotrophic factor (GDNF). His parkinsonism continued to worsen following intracerebroventricular GDNF treatment. Side effects included nausea, loss of appetite, tingling, L'hermitte's sign, intermittent hallucinations, depression, and inappropriate sexual conduct. There was no evidence of significant regeneration of nigrostriatal neurons or intraparenchymal diffusion of the intracerebroventricular GDNF to relevant brain regions. Alternative GDNF delivery systems should be explored.

Publication Date

9-13-1999

Publication Title

Annals of Neurology

ISSN

03645134

Volume

46

Issue

3

First Page

419

Last Page

424

PubMed ID

10482276

Digital Object Identifier (DOI)

10.1002/1531-8249(199909)46:3<419::AID-ANA21>3.0.CO;2-Q

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