Title

Segregation of the yeast plasmid: Similarities and contrasts with bacterial plasmid partitioning

Document Type

Article

Abstract

The high copy yeast plasmid 2μm circle, like the well-studied low copy bacterial plasmids, utilizes two partitioning proteins and a cis-acting 'centromere'-like sequence for its stable propagation. Functionally, though, the protein and DNA constituents of the two partitioning systems are quite distinct. Key events in the yeast and bacterial segregation pathways are plasmid organization, localization, replication, 'counting' of replicated molecules and their distribution to daughter cells. We suggest that the two systems facilitate these common logistical steps by adapting to the physical, biochemical, and mechanical contexts in which the host chromosomes segregate. © 2004 Elsevier Inc. All rights reserved.

Publication Date

5-1-2004

Publication Title

Plasmid

ISSN

0147619X

Volume

51

Issue

3

First Page

162

Last Page

178

PubMed ID

15109823

Digital Object Identifier (DOI)

10.1016/j.plasmid.2004.02.005

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