Trajectories of stroke recovery of impairment, function, and quality of life in response to 12-month mobility and fitness intervention
BACKGROUND: Gait deficits and functional disability are persistent problems for many stroke survivors, even after standard neurorehabilitation. There is little quantified information regarding the trajectories of response to a long-dose, 12-month intervention. OBJECTIVE: We quantified treatment response to an intensive neurorehabilitation mobility and fitness program. METHODS: The 12-month neurorehabilitation program targeted impairments in balance, limb coordination, gait coordination, and functional mobility, for five chronic stroke survivors. We obtained measures of those variables every two months. RESULTS: We found statistically and clinically significant group improvement in measures of impairment and function. There was high variation across individuals in terms of the timing and the gains exhibited. CONCLUSIONS: Long-duration neurorehabilitation (12 months) for mobility/fitness produced clinically and/or statistically significant gains in impairment and function. There was unique pattern of change for each individual. Gains exhibited late in the treatment support a 12-month intervention. Some measures for some subjects did not reach a plateau at 12 months, justifying further investigation of a longer program (>12 months) of rehabilitation and/or maintenance care for stroke survivors.
Stroke, balance, coordination, functional mobility, gait, gait speed, quality of life
Medical Subject Headings
Exercise Therapy; Gait; Humans; Quality of Life; Recovery of Function; Stroke (complications); Stroke Rehabilitation; Survivors
Digital Object Identifier (DOI)
Boissoneault, Catherine; Rose, Dorian K.; Grimes, Tyler; Waters, Michael F.; Khanna, Anna; Datta, Somnath; and Daly, Janis J., "Trajectories of stroke recovery of impairment, function, and quality of life in response to 12-month mobility and fitness intervention" (2021). Translational Neuroscience. 1347.