Title

Non-linearity in invasive EEG recordings from patients with temporal lobe epilepsy

Document Type

Article

Abstract

Electrographic recordings from depth and subdural electrodes, performed in two patients with seizures of mesial temporal origin, were analyzed for the presence of non-linearities in the signal. The correlation integral, a measure sensitive to a wide variety of non-linearities, was used for detection. Statistical significance was determined by comparison of the original signal to surrogate datasets. Statistically significant non-linearities were present in signals generated by the epileptogenic hippocampus and interictal spike foci in the temporal neocortex. Less prominent non-linearities were found in EEG signals generated by more normal areas of the brain. These results indicate that techniques developed for the study of non-linear systems can be used to characterize the epileptogenic regions of the brain during the interictal period and can elucidate the dynamical mechanisms of the epileptic transition.

Medical Subject Headings

Electroencephalography; Epilepsy, Temporal Lobe (physiopathology); Humans

Publication Date

2-1-1997

Publication Title

Electroencephalography and clinical neurophysiology

ISSN

0013-4694

Volume

102

Issue

2

First Page

98

Last Page

105

PubMed ID

9060860

Digital Object Identifier (DOI)

10.1016/s0921-884x(96)95195-4

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