Epileptic focus localization based on resting state interictal MEG recordings is feasible irrespective of the presence or absence of spikes
Document Type
Article
Abstract
OBJECTIVE: To investigate whether epileptogenic focus localization is possible based on resting state connectivity analysis of magnetoencephalographic (MEG) data. METHODS: A multivariate autoregressive (MVAR) model was constructed using the sensor space data and was projected to the source space using lead field and inverse matrix. The generalized partial directed coherence was estimated from the MVAR model in the source space. The dipole with the maximum information inflow was hypothesized to be within the epileptogenic focus. RESULTS: Applying the focus localization algorithm (FLA) to the interictal MEG recordings from five patients with neocortical epilepsy, who underwent presurgical evaluation for the identification of epileptogenic focus, we were able to correctly localize the focus, on the basis of maximum interictal information inflow in the presence or absence of interictal epileptic spikes in the data, with three out of five patients undergoing resective surgery and being seizure free since. CONCLUSION: Our preliminary results suggest that accurate localization of the epileptogenic focus may be accomplished using noninvasive spontaneous "resting-state" recordings of relatively brief duration and without the need to capture definite interictal and/or ictal abnormalities. SIGNIFICANCE: Epileptogenic focus localization is possible through connectivity analysis of resting state MEG data irrespective of the presence/absence of spikes.
Keywords
Epilepsy, Epileptogenic focus localization, Information flow, Interictal period, MEG, Resting state connectivity
Medical Subject Headings
Action Potentials (physiology); Adult; Electroencephalography (methods); Epilepsies, Partial (diagnosis, physiopathology); Feasibility Studies; Female; Humans; Magnetoencephalography (methods); Male; Middle Aged; Rest (physiology)
Publication Date
4-1-2015
Publication Title
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
E-ISSN
1872-8952
Volume
126
Issue
4
First Page
667
Last Page
74
PubMed ID
25440261
Digital Object Identifier (DOI)
10.1016/j.clinph.2014.07.014
Recommended Citation
Krishnan, B; Vlachos, I; Wang, Z I.; Mosher, J; Najm, I; Burgess, R; Iasemidis, L; and Alexopoulos, A V., "Epileptic focus localization based on resting state interictal MEG recordings is feasible irrespective of the presence or absence of spikes" (2015). Translational Neuroscience. 1148.
https://scholar.barrowneuro.org/neurobiology/1148