Brain dynamical disentrainment by anti-epileptic drugs in rat and human status epilepticus

Document Type

Article

Abstract

In this paper, we utilize a measure of brain dynamics, namely the short-term largest Lyapunov exponent (STLmax) to evaluate the efficacy of treatment in epileptic animals and humans with known antiepileptic drugs (AED) like diazepam and phenobarbital during status epilepticus (SE). This measure is estimated from analysis of electroencephalographic (EEG) recordings at multiple brain locations in both an SE patient and a cobalt/homocysteine thiolactone SE-induced animal. Techniques from optimization theory and statistics are applied to select optimal sets of brain sites, whose dynamics are then measured over time to study their entrainment/disentrainment. Results from such analysis indicate that the observed abnormal spatio-temporal dynamical entrainment in SE is reversed by AED administration (resetting of brain dynamics). These results may provide a potential use of nonlinear dynamical measures in the evaluation of the efficacy of AEDs and the development of new treatment strategies in epilepsy.

Publication Date

9-1-2004

Publication Title

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

ISSN

1557-170X

Volume

2006

First Page

176

Last Page

9

PubMed ID

17271634

Digital Object Identifier (DOI)

10.1109/IEMBS.2004.1403120

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