Total mandibulectomy defect in the setting of chronic bisphosphonate use
Document Type
Article
Abstract
Bisphosphonates are among several drugs known in modern medicine to have a potentially deleterious effect on the mandible with chronic use. While purportedly causing a necrotic reaction in the bone, the complete mechanism is not fully elucidated yet as cases are quite rare in the general public. Despite the esoteric nature of this entity, patients suffering from bisphosphonate induced necrosis have a complicated and prolonged course often involving varying degrees of mandibular debridement with severe cases requiring reconstruction. In this report, we present the unique case of a patient with a progressive mandibular osteonecrosis requiring complete mandibulectomy and fibula flap reconstruction.
Medical Subject Headings
Bone Density Conservation Agents (administration & dosage, adverse effects); Diphosphonates (administration & dosage, adverse effects); Humans; Male; Mandibular Diseases (chemically induced, pathology, surgery); Mandibular Osteotomy; Middle Aged; Osteonecrosis (chemically induced, pathology, surgery)
Publication Date
9-1-2018
Publication Title
American journal of otolaryngology
E-ISSN
1532-818X
Volume
39
Issue
5
First Page
649
Last Page
651
PubMed ID
29778637
Digital Object Identifier (DOI)
10.1016/j.amjoto.2018.05.004
Recommended Citation
Jategaonkar, Ameya A.; Badhey, Arvind K.; Sokoya, Mofiyinfolu; Kadakia, Sameep; Mudrovich, Steven; and Ducic, Yadranko, "Total mandibulectomy defect in the setting of chronic bisphosphonate use" (2018). ENT and Skull Base Surgery. 15.
https://scholar.barrowneuro.org/ent-and-skull-base-surgery/15