Liver Cirrhosis and Inpatient Mortality in Aneurysmal Subarachnoid Hemorrhage: A Propensity-Adjusted Analysis
Document Type
Article
Abstract
OBJECTIVE: Liver cirrhosis is associated with an increased risk of aneurysmal subarachnoid hemorrhage (aSAH). However, large studies analyzing the prognosis of cirrhotic patients after aSAH treatment are lacking. This study explores factors associated with inpatient mortality among aSAH patients with cirrhosis. METHODS: All patients who underwent open or endovascular treatment for an aSAH at a large quaternary center between January 1, 2003, and July 31, 2019, were retrospectively reviewed. Patients were grouped into cirrhosis versus noncirrhosis groups. Univariate analysis determined variables associated with inpatient mortality. Variables with P < 0.20 were included in a propensity-adjusted multivariable logistic regression analysis to predict inpatient mortality. RESULTS: A total of 1419 patients were treated for aSAH; 17 (1.2%) had confirmed cirrhosis. Inpatient mortality was significantly higher among cirrhotic patients than noncirrhotic patients (35.3% vs. 6.8%; P < 0.001). In the univariate analysis for inpatient mortality, the variables cirrhosis, age >65 years, Charlson Comorbidity Index >4, aneurysm size ≥10 mm, Hunt and Hess grade >3, Fisher grade 4, delayed cerebral ischemia (DCI), and posterior circulation aneurysm had P < 0.20 and were included in the multivariable analysis. The propensity-adjusted stepwise multivariable logistic regression analysis showed that cirrhosis (odds ratio [OR]: 12.7, 95% confidence interval [CI]: 3.3-48.7), Hunt and Hess grade >3 (OR: 3.9, 95% CI: 2.3-6.4), Fisher grade 4 (OR: 3.7, 95% CI: 1.3-10.7), and DCI (OR: 2.4, 95% CI: 1.5-3.9) were associated with inpatient mortality (P ≤ 0.01). CONCLUSIONS: Cirrhosis was a predictor of inpatient mortality among aSAH patients and was a stronger predictor than DCI or a poor Hunt and Hess grade among patients in this study.
Medical Subject Headings
Humans; Aged; Subarachnoid Hemorrhage (complications); Retrospective Studies; Inpatients; Prospective Studies; Brain Ischemia (etiology); Cerebral Infarction (complications); Liver Cirrhosis (complications)
Publication Date
11-1-2022
Publication Title
World neurosurgery
E-ISSN
1878-8769
Volume
167
First Page
e948
Last Page
e952
PubMed ID
36055622
Digital Object Identifier (DOI)
10.1016/j.wneu.2022.08.113
Recommended Citation
Catapano, Joshua S.; Lee, Katriel E.; Rumalla, Kavelin; Srinivasan, Visish M.; Cole, Tyler S.; Baranoski, Jacob F.; Winkler, Ethan A.; Graffeo, Christopher S.; Alabdly, Muhaiman; Jha, Ruchira M.; Jadhav, Ashutosh P.; Ducruet, Andrew F.; Albuquerque, Felipe C.; and Lawton, Michael T., "Liver Cirrhosis and Inpatient Mortality in Aneurysmal Subarachnoid Hemorrhage: A Propensity-Adjusted Analysis" (2022). Neurology. 1348.
https://scholar.barrowneuro.org/neurology/1348