IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase.

Document Type

Article

Abstract

Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/ inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.

Keywords

Humans, Interleukin-11, Interleukin-11 Receptor alpha Subunit, Internet, Knowledge Bases, Signal Transduction

Medical Subject Headings

Humans; Interleukin-11; Interleukin-11 Receptor alpha Subunit; Internet; Knowledge Bases; Signal Transduction

Publication Date

8-1-2013

Publication Title

Cell communication & adhesion

ISSN

1543-5180

Volume

20

Issue

3-4

First Page

81

Last Page

86

PubMed ID

23631681

Digital Object Identifier (DOI)

10.3109/15419061.2013.791683

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