Remote Ischemic Post-Conditioning (RIC) Mediates Anti-Inflammatory Signaling via Myeloid AMPKα1 in Murine Traumatic Optic Neuropathy (TON).
Document Type
Article
Abstract
Traumatic optic neuropathy (TON) has been regarded a vision-threatening condition caused by either ocular or blunt/penetrating head trauma, which is characterized by direct or indirect TON. Injury happens during sports, vehicle accidents and mainly in military war and combat exposure. Earlier, we have demonstrated that remote ischemic post-conditioning (RIC) therapy is protective in TON, and here we report that AMPKα1 activation is crucial. AMPKα1 is the catalytic subunit of the heterotrimeric enzyme AMPK, the master regulator of cellular energetics and metabolism. The α1 isoform predominates in immune cells including macrophages (Mφs). Myeloid-specific AMPKα1 KO mice were generated by crossing AMPKα1
Keywords
Animals, Mice, AMP-Activated Protein Kinases, Signal Transduction, Optic Nerve Injuries, Mice, Knockout, Ischemic Postconditioning, Male, Mice, Inbred C57BL, Macrophages, Disease Models, Animal, Female, Myeloid Cells, Retinal Ganglion Cells, Transcription Factor Brn-3A
Medical Subject Headings
Animals; Mice; AMP-Activated Protein Kinases; Signal Transduction; Optic Nerve Injuries; Mice, Knockout; Ischemic Postconditioning; Male; Mice, Inbred C57BL; Macrophages; Disease Models, Animal; Female; Myeloid Cells; Retinal Ganglion Cells; Transcription Factor Brn-3A
Publication Date
12-19-2024
Publication Title
Int J Mol Sci
ISSN
1422-0067
Volume
25
Issue
24
PubMed ID
39769388
Digital Object Identifier (DOI)
10.3390/ijms252413626
Recommended Citation
Akhter, Naseem; Contreras, Jessica; Ansari, Mairaj A; Ducruet, Andrew F.; Hoda, Md Nasrul; Ahmad, Abdullah S; Gangwani, Laxman D; Bhatia, Kanchan; and Ahmad, Saif, "Remote Ischemic Post-Conditioning (RIC) Mediates Anti-Inflammatory Signaling via Myeloid AMPKα1 in Murine Traumatic Optic Neuropathy (TON)." (2024). Translational Neuroscience. 2437.
https://scholar.barrowneuro.org/neurobiology/2437